Selection and Characterization of Human PCSK9 Antibody from Phage Displayed Antibody Library

Cao Y, et al., 7;463(4):712-8, Biochem Biophys Res Commun, 2015

The discovery of a novel antibody for Proprotein convertase subtilisin/kexin type 9 (PCSK9) is reported in this article. The authors used a phage-display antibody library against recombinant PCSK9 to obtain a fully human IgG1-PA4 antibody that is specific for PCSK9. A BLItz system equipped with Protein A biosensors allowed IgG1-PA4 capture and kinetic characterization of its binding to PCSK9.

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