Ribosomal Protein S19 Binding Domain Provides Insights into Hantavirus Nucleocapsid Protein-mediated Translation Initiation Mechanism

Ganaie SS, et al., doi:10.1042/BJ20140449, Biochem J, 2014

The authors performed structural and functional analysis to identify and characterize the ribosomal protein S19 (RPS-19) binding domain in the nucleocapsid (N) protein of hantavirus, the RNA virus responsible for causing haemorrhagic fever and hantavirus cardiopulmonary syndrome. The results demonstrated the interaction of N-RPS19 as a novel target for therapeutic intervention of hantavirus diseases. Binding affinities were determined using the Blitz system along with Streptavidin biosensors.

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