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Receptor Binding by an H7N9 Influenza Virus from Humans

Xiong X, et al., 499(7459), 496-9, Nature, 2013

This study examines the receptor-binding properties of the H7N9 influenza virus and compares them with those of an avian H7N3 virus. The authors conclude that the human H7 virus has acquired some of the receptor-binding characteristics that are typical of pandemic viruses, but its retained preference for avian receptor may restrict its further evolution towards a virus that could transmit efficiently between humans. Virus binding to receptor analogues was characterized on an Octet RED system using biotinylated α2,3- and α2,6-linked sialyl lactosamine sugars loaded onto Streptavidin biosensors.

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