Rapid Identification of Production Strains

Kumaraswamy, S.; Allen, J. R., June 15, 30 (12), Genetic and Engineering News, 2010

This article describe the implementation of Octet systems at Pfenex for high-throughput identification of optimal production strains. Details are presented about a Pfenex screen of 240 unique strains for expression of soluble, correctly folded granulocyte colony stimulating factor (GCSF). The authors report that Pfenex has implemented expression screens for diverse classes of proteins, including mAbs, Fab, single-chain antibodies, growth factors, cytokines and vaccine antigens.

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