Quantum Dot-induced Viral Capsid Assembling in Dissociation Buffer

Gao D, et al., 8, 2119-2128, International Journal of Nanomedicine, 2013

This study reports that the capsid protein VP1 can assemble into capsids in the presence of quantum dots (QDs), and that the QDs are encapsulated in the SV40 capsids. BLI studies showed a strong interaction between the QDs and SV40 VP1 proteins. Binding kinetics of VP1 to mercaptoproprionic acid-QDs and VP1 pentamers were measured using the Octet RED96 system with biotinylated VP1 loaded onto Streptavidin biosensors.

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