Preexisting Immunity, More Than Aging, Influences Influenza Vaccine Responses

Reber A, et al., doi: 10.1093/ofid/ofv052, Oxford Journals, 2015

An assessment of physiological factors that affect immune responses of older adults to the 2008-2009 seasonal trivalent inactivated influenza vaccine (TIV) is reported. The hemagglutination inhibition (HI) assay revealed vaccine's capability to produce an immune response. A Pall ForteBio Octet RED instrument was used in the analysis of binding between serum antibodies and hemagglutinin (HA). Overall results demonstrate a major impact coming from pre-vaccination responses on the post-vaccination antibody levels regardless of the age group.

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