Polymeric Penetration Enhancers Promote Humoral Immune Responses to Mucosal Vaccines

Klein K, et al., 183:43-50, J Control Release, 2014

This report described the used of three commonly used penetration enhancers to promote trans-muscosal bioavailability of insulin and two vaccine candidates as biomarkers for mucosal absorption to test the theory that the mucosal immune responses is more efficiently activated after direct mucosal application compared to parenteral routes of vaccination. Binding interactions were carried out on the Blitz system and Amine reactive (ARG2) biosensors were used.

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