Physicochemical and Biological Characterization of a Biosimilar Trastuzumab

Lopez-Morales C, et al., 2015:427235, Biomed Res Int, 2015

This is a comparability study of a biosimilar trastuzumab with respect to its reference product to evaluate the physicochemical and biological aspects. Trastuzumab is a monoclonal antibody that interferes with the human epidermal growth factor receptor (HER2), which overexpresses in certain invasive forms of breast cancers. A Pall ForteBio Octet QK384 instrument equipped with Streptavidin Biosensor probes captured with Biotinylated FcRn investigated the binding of trastuzumab to FcRn. Overall results of this investigation suggest that there is a high degree of similarity in the physicochemical properties of the biosimilar trastuzumab with respect to the reference product as evident from comparable biological activity.

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