Peptide Microarrays Enable Rapid Mimotope Optimization for Pharmacokinetic Analysis of the Novel Therapeutic Antibody IMAB362

Schnatbaum K, et al., 9(4):545-54, Biotechnol J, 2014

This article described the screening of a peptide library for mimotopes that are detected by the novel cancer therapeutic antibody IMAB362. Mimotopes are candidate substitutions for target proteins that can be difficult to produce or handle and can be used for pre-clinical and clinical assay or for the purification of biological products. Binding studies were performed on the Octet RED system using Streptavidin biosensors.

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