Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models

Sankaranarayanan S, et al., 10(5):e0125614, PLoS One, 2015

This is a study on phospho-tau (p-tau) antibodies (PHF6 and PHF13) with ability to target pT231 and pS396 sites, respectively. These two p-tau antibodies are capable of preventing the induction of tau pathology in primary neuron cultures and in two distinct transgenic mouse tauopathy models. Antibody affinity studies were carried out with a Pall ForteBio Octet Red instrument equipped with Streptavidin Biosensor probes. Biotinylated phospho-peptides were immobilized on to Streptavidin probes. Association & dissociation kinetics and the binding affinity constant (KD) of respective antibodies were determined. Overall results contribute significantly towards the probable use of tau immunotherapy for the treatment of Alzheimer's disease (AD) and related tauopathies.

Read More