Paramagnetic Solid Lipid Nanoparticles as a Novel Platform for the Development of Molecular MRI Probes

Rolla G, et al., 19(34), 11189-93, Chemistry, 2013

In this study, solid lipid nanoparticles (SLNs), based on crystalline triglyceride, are investigated as an alternative delivery system for MRI probes based on Gd(III) complexes. The Octet QK system was used to characterize the targeting properties of folic acid-pSLNs to an anti-folic acid monoclonal antibody. Protein A biosensors were loaded with the anti-folic acid mAb for binding studies.

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