Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms

Lelliott C, et al., 9(11):e112109, PLoS One, 2014

This article describes the phage display identification of a novel fully human fibroblast growth factor receptor 1 (FGFR1c) targeting monoclonal antibody called R1c mAb. It causes significant body fat and weight loss in diet-induced obese mice due to reduced food intake. The receptor binding assays performed using an Octet RED system involved label-free analysis between R1c mAb and FGFR1c. The R1c mAb or a control mAb captured on to SA biosensors via a biotinylated Protein G was instrumental in monitoring the association and dissociation of receptor.

Read More