Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation

Yin Q, et al., 4(2), 327-39, Cell Rep, 2013

To elucidate the role of p202 in the regulation of cytosolic DNA sensing, the authors performed extensive structural, biochemical, and cellular studies. The BLItz system was used for binding studies of HIN (hemopoietic expression, interferon inducibility, nuclear localization) proteins. Human AIM2 HIN, IFI16 HIN1 or HIN2 were biotinylated and immobilized on Streptavidin biosensors for binding studies.

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