Metformin Interacts with AMPK Through Binding to γ Subunit

Zhang, Y., et al., 368(1-2), 69-76, Mol Cell Biochem, 2012

Metformin is a commonly used drug to treat type 2 diabetes. Octet systems and other techniques including CD, fluorescence spectroscopy were employed to study the binding relationship between Metformin and AMPK, a kinase that is a key regulator of energy metabolism and the target of Metformin.

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