Mechanistic Study of Broadly Neutralizing Human Monoclonal Antibodies Against Dengue Virus that Target the Fusion Loop

Costina, J M, et al., 87(1), 52-66, J Virol, 2013

The authors identified and characterized three broadly neutralizing, high affinity human monoclonal antibodies to Dengue Virus. The Octet QK system was used to study the binding of these hMAbs to Dengue Virus -1, -2, -3, and -4 soluble E proteins, and to perform antibody binding competition assays. For all Octet experiments, hMAbs were loaded onto Anti-Human IgG Fc Capture (AHC) biosensors.

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