Lycium Barbarum Polysaccharide LBPF4-OL may be a New Toll-like Receptor 4/MD2-MAPK Signaling Pathway Activator and Inducer

Zhang XR, et al., 19(1):132-141, Int Immunopharmacol, 2014

The authors report on the first demonstration that Lycium barbarum polysaccharide (LBP) stimulates tumor necrosis factor-alpha (TNF-α) and IL-1β generation and promotes lymphocyte proliferation in the Toll-like Receptor 4 (TLR 4)/MD2-MAPK signaling pathway. LBP is the main active ingredient in L. barbaum has been reported to have immunoregulation and antitumor effects. Kinetic binding experiments were performed on the Octet RED system using Anti-Human IgG FC Capture (AHC) biosensors.

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