Label Free Inhibitor Screening of Hepatitis C Virus (HCV) NS5B Viral Protein Using RNA Oligonucleotide

Roh, C.; Kim, S.E.; Jo, SK., 11(7), 6685-6696, Sensors (Basel), 2011

The authors demonstrate that the hepititis C viral protein NS5B can be detected and monitored using an immobized RNA aptamer on the Octet QK system. The biotinylated RNA strand was loaded onto Streptavidin biosensors and incubated with a dilution series of NS5B protein. A detection limit of 700 pg/mL was reported.

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