Publications

Label-Free Detection of Small-Molecule Binding to a GPCR in the Membrane Environment

Heym R, et al., 1854(8):979-86, Biochim Biophys Acta, 2015

This article reports a comparative analysis of G-protein-coupled receptor (CXCR4) binding to a small molecule ligand AMD3100 using SAW, SPR, and BLI technologies. The data obtained from SAW and SPR compared directly with previously published data from BLI and radioligand-binding experiments. Since the current data is in agreement with prior data, the authors concluded that SAW can be as reliable as more established techniques such as SPR, BLI, and radioligand binding experiments.

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