Isolation of Dengue Virus-specific Memory B Cells with Live Virus Antigen from Human Subjects Following Natural Infection Reveals the Presence of Diverse Novel Functional Groups of Antibody Clones

Smith SA, et al., pii: JVI.00247-14, J Virol, 2014

The authors performed a focused screening and characterization of inhibitory antibodies to dengue virus infection in humans. The results revealed that humans have the potential to generate very potent antibodies which are antigenic to diverse regions of the dengue virus surface protein. Binding studies were performed on the Octet RED system using Anti-mouse IgG FC (AMQ) biosensors.

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