Intravenous Immunglobulin Binds Beta Amyloid and Modifies Its Aggregation, Neurotoxicity and Microglial Phagocytosis In Vitro

Cattepoel S, et al., 8(5):e63162, PLoS One, 2013

This study investigates the effects of intravenous immunoglobulins (IVIG) and purified polyclonal amyloid β-specific antibodies on aggregation, toxicity and phagocytosis of Aβ in vitro, thus elucidating some of the potential mechanisms of action of IVIG in Alzheimer's disease patients. The Octet QKe was used for binding studies of amyloid β-specific antibodies, IVIG, and Aβ. Biotinylated Aβ oligomers were loaded onto Streptavidin biosensors for these experiments.

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