Inhibition of Hepatitis C Virus by the Cyanobacterial Protein MVL: Mechanistic Differences Between the High-mannose Specific Lectins MVL, CV-N, and GNA

Kachko A, et al., 10, 4590_4602, Mol Pharm, 2013

The authors investigate the antiviral properties of the newly discovered Microcystis viridis lectin (MVL) along with cyanovirin-N (CV-N) and Galanthus nivalis agglutinin (GNA) against cell culture Hepatitis C Virus (HCV), as well as their binding properties toward viral particles, target cells, and recombinant HCV glycoproteins. The Octet RED96 system was used for various binding and kinetics experiments with biotinylated HCV rE1E2 protein loaded onto Streptavidin biosensors.

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