Improving the Anti-Toxin Abilities of the CMG2-Fc Fusion Protein with the Aid of Computational Design

Xi Y, et al., 9(8):e104674, PLoS One, 2014

Computational design and functional analysis was employed in a rat model system to generate a capillary morphogenesis protein 2(CMG2) fusion protein with improved protein-binding affinity and therapeutic efficacy to anthrax infection. Binding kinetics by the mutant fusion proteins for the protective antigen (PA) were performed on the Octet QK system using Anti-Human IgG Fc (AHC) biosensors.

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