IL-13-induced Airway Mucus Production is Attenuated by MAPK13 Inhibition

Alevy, Y. G., et al., 122(12), 4555-68, J Clin Invest, 2012

Genetic and chemical tools are used to define a signaling pathway controlling mucous production, beginning with IL-13 induction of CLCA1-gene expression to CLCA1-mediated activation of MAPK13, followed by induction of mucin gene expression. Using structure-based drug design, a series of nM affinity MAPK13 inhibitors were developed. Kinetics of MAPK13 binding to these inhibitors was assessed with the Octet system and Super Streptavidin biosensors.

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