Heavy Chain-Only Antibodies and Tetravalent Bispecific Antibody Neutralizing Staphylococcus Aureus Leukotoxins

Laventie, B.J., et al., 108 (39), 16404-16409, Proc Natl Acad Sci USA, 2011

The actions of humanized heavy-chain only antibodies (HCAb) and a tetravalent bispecific HCAb against components of Panton-Valentine leukocidin are studied in the publication. The Octet QK was used to assess the binding of the bispecific HCAb, e.g. to demonstrate that it binds to both antigens simultaneously.

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