Exploration of the HIF-1α/p300 Interface Using Peptide and Adhiron Phage Display Technologies

Kyle H, et al., DOI: 10.1039/C5MB00284B, Mol Biosyst, 2015

This study has explored the use of peptide and adhiron phage-display capabilities to deepen the understanding of HIF-1α/p300 protein-protein interaction. This interaction is crucial for tumor metabolism and plays as a drug target for anticancer drug development. A Pall ForteBio Blitz system equipped with Ni-NTA Biosensor probes was used to capture adhirons and to estimate binding with p300.

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