Effects on Peptide Binding Affinity for TNFα by PEGylation and Conjugation to Hyaluronic Acid

Elder A, et al., 49, 2968-2975, European Polymer Journal, 2013

This study uses a model peptide inhibitor of TNF-α to investigate the effects of site-specific conjugation to hyaluronic acid and polyethylene glycol. Binding affinities and kinetic rate constants for the conjugated and unconjugated biotinylated peptides were determined using the Octet QK system and Streptavidin biosensors.

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