Discovery of Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

Jiang ZY, et al., 57(6):2736-45, J Med Chem, 2014

Structural and functional analysis were performed on a newly identified a potent small molecule E3 ligase inhibitor designated compound 2, which directly targets protein-protein interactions and provides a strategy to develop a novel class of antioxidant, anti-inflammatory and anti-cancer agents. Binding interactions of ligands and the Keap1 DC domain protein were performed on the Octet RED96 system using Super Streptavidin biosensors.

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