Directed Evolution of Multivalent Glycopeptides Tightly Recognized by HIV Antibody 2G12

Horiya S, et al., 136(14):5407-15, J Am Chem Soc, 2014

The authors presented a screening strategy to identify and select multivalent glycopeptides that showed strong picomolar to low nanomolar affinity for the HIV broadly neutralizing antibody 2G12 as a method to generate new HIV vaccine candidates. Binding studies were performed on the Blitz system, using Streptavidin biosensors.

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