Development and Characterization of APRIL Antagonistic Monoclonal Antibodies for Treatment of B-Cell Lymphomas

Guadagnoli, M., et al., 117(25), 6856-6865, Blood, 2011

APRIL (a proliferation-inducing ligand) is a TNF family member that binds TACI and BCMA. APRIL is a growth promoter of solid tumors, and an important survival factor in B-cell malignancies, such as CLL. The authors develop two anti-human APRIL antogonist monoclonal antibodies. Kinetic analysis of mAb association/dissociation rates to hAPRIL was performed on the Octet system by coupling the purified antibodies to Amine Reactive biosensors.

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