Design of a Potent Antibiotic Peptide Based on the Active Region of Human Defensin 5

Wang C, et al., 58(7):3083-93, J Med Chem, 2015

The design of a novel antibiotic peptide based on the active region of human defensin 5 (HD5) is described in this article. It provides a useful guide as to how the increase in electropositive charge can be compensated for an impaired ability to assemble and hence for future defensin-based antibiotic design. A Pall ForteBio Octet RED96 system equipped with AR2G biosensors was used to determine binding kinetics between the peptides and bacterial lipid A and lipoteichoic acid (LTA).

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