Data Fusion-based Assessment of Raw Materials in Mammalian Cell Culture

Lee, H., Christie, A., Xu, J., Yoon, S., 109(11), 2819-28, Biotechnology and Bioengineering, 2012

This is a process analytical study in which four spectroscopic techniques (NIR, 2D fluorescence, Raman and X-ray fluorescence) were used to predict the raw material quality of soy hydrolysate samples in CHO cell culture. Intergrated viable cell density and IgG production were used as quantitative indices of raw material quality. The Octet QK system was used to determine IgG production levels.

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