Coagulation Factor X Shields Adenovirus Type 5 from Attack by Natural Antibodies and Complement

Xu, Z, et al., 19(4), 452-7, Nat Med, 2013

Adenovirus type 5 (Ad5) can survive attack by natural antibodies and complement, making it a valuable vector for systemic gene therapy. Results presented in this paper demonstrate that resistance of Ad5 to complement is dependent on recruitment of and binding to coagulation factor X (FX). The Octet RED system and Streptavidin biosensors were used to analyze interactions of FX with non-FX-binding mutant Ad vector and corresponding control.

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