Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia

Souders C, et al., 16(6):12436-53, Int J Mol Sci, 2015

This article describes the development and application of diagnostic antibodies that are specific to the splice variants of soluble fms-like tyrosine kinase 1 (sFlt1), namely sFlt1-1 and sFlt1-14. A Pall ForteBio Octet QK system equipped with anti-murine or anti-human biosensors was used to determine binding affinities. The authors assume that these isoform specific biomarkers could be used to predict preeclampsia in pregnant women.

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