Chemical and Genetic Evidence for the Involvement of Wnt Antagonist Dickkopf2 in Regulation of Glucose Metabolism

Li, X., et al., 109(28), 11402-7, Proc Natl Acad Sci USA, 2012

This study concludes that the naturally-occuring Wnt antagonist Dickkopf2 (DKK2) may be a potential therapeutic target for type 2 diabetes. The authors use the Octet RED system to characterize the binding of DKK2C to repeat domains of the Wnt coreceptor LRP6 , and the inhibition constant for a small molecule inhibitor of that interaction.

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