Boosting Antibody Developability Through Rational Sequence Optimization

Seeliger D, et al., 7(3):505-15, MAbs, 2015

This study reports computational approaches based on sequence analyses that could be used to modify an antibody sequence to prevent it from precipitation and to improve its stability in vitro. A Pall ForteBio Octet system equipped with Protein A biosensors was used to estimate productivity of cell cultures by titer measurements.

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