Bisubstrate UDP-peptide Conjugates as Human O-GlcNAc Transferase Inhibitors

Borodkin VS, et al., 457, 497-502, Biochem J, 2014

This study reports on the rational design of new bisubstrate inhibitors of O-GlcNAc transferase (OGT) that combine elements of both substrates. The Octet RED384 system was used to measure binding affinities of inhibitors for hOGT, with biotinylated hOGT loaded onto Super Streptavidin biosensors.

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