Antibody-based Prevention of von Willebrand Factor Degradation Mediated by Circulatory Assist Devices

Rauch A, et al., 112(5), Thromb Haemost, 2014

This report described the screening of protein fragments and monoclonal murine antibodies that interact with von Willebrand factor (VWF), a glycoprotein that has a key role in the formation of platelet-rich thrombin, particularly under conditions of high shear stress. The goal was to develop a strategy to treat bleeding episodes due to shear stress-dependent VWF degradation. Equilibrium binding assays were performed using the Octet QK system. Protein A-coated biosensors were used.

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