Anti-HIV-1 Activity and Structure-activity-relationship Study of a Fucosylated Glycosaminoglycan from an Echinoderm by Targeting the Conserved CD4 Induced Epitope

Lian W, et al., 1830(10), 4681-91, Biochim Biophys Acta, 2013

Fucosylated glycosaminoglycan (FG) is a novel glycosaminoglycan with a chondroitin sulfate-like backbone and fucose sulfate branches. The aim of this study was to investigate the mechanism and structure-activity relationships of FG for combating HIV-1 infection. The Octet RED96 system was used to study the binding of FGs and gp120, and the effects of CD4 on that binding. For these studies, FGs were biotinylated and loaded onto Streptavidin biosensors.

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