An Inhibitory Antibody against Dipeptidyl Peptidase IV Improves Glucose Tolerance In Vivo

Tang, J, et al., 288(2), 1307-16, J Biol Chem, 2013

The authors generated and characterized tight-binding inhibitory mAbs against rat dipeptidyl peptidase IV (DPP-IV), an enzyme whose suppression is an established strategy to treat type 2 diabetes mellitus. The Octet system was used to study mAb binding to rat DPP-IV, and to identify the key recognition epitope. Protein G biosensors were used for the binding experiments.

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