Adenanthin Targets Peroxiredoxin I and II to Induce Differentiation of Leukemic Cells

Liu, C.X., et al., 8(5), 486-93, Nature Chemical Biology, 2012

The authors report that adenanthin, a diterpenoid, binds to Peroxiredoxins I and II and inhibits their peroxidase activities. The Octet RED system was used to characterize initial noncovalent binding of wild-type and mutant Peroxiredoxin I and Peroxiredoxin II to biotin-adenanthin.

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