A TPO Receptor Agonist, ALXN4100TPO, Mitigates Radiation-Induced Lethality and Stimulates Hematopoiesis in CD2F1 Mice

Satyamitra, M., et al., 175 (6), 746-758, Radiation Research, 2011

A TPO agonist peptide was grafted into the human antibody against anthrax, resulting in a series of 4100TPO agonist variants with utility as radiation countermeasure agents. The binding kinetics of the variants with the human TPO receptor were quantified using the Octet RED platform by immobilizing biotinylated c-Mpl-r on Streptavidin biosensors and then characterizing association and dissociation rates for the different variants.

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