A Novel VHH Antibody Targeting the B Cell-Activating Factor for B-Cell Lymphoma

Wu W, et al., 15(6):9481-96, Int J Mol Sci, 2014

The study describes the generation of single-domain anti-B cell activating factor (BAFF) camel antibodies from heavy chain variable domain phage display libraries as well as the panning, expression and functional characterization of the antibodies to understand their specificity to BAFF. The antibodies identified provide new options for targeting tumors for B cell lymphoma diagnosis or therapy. The relative binding affinities of the different sdAb against BAFF was performed on the Octet RED system using Streptavidin biosensors.

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