Publications

A Novel Process for Developing Fully Human Monoclonal Antibodies

Schram, B., et al., 11(36), s28-s31, Pharmaceutical Technology, 2012

The authors describe Neoclone's human-mAb platform for generation of fully human therapeutic antibodies. In the NeoAb approach, antigen supernatants from cultured B cells are tested for affinity and specificity using the Octet QK system. Streptavidin biosensors loaded with biotinylated antigens are employed for binding constant determinations of purifies antibodies and for KD rank-ordering of crude tissue culture supernatants.

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