A Neutralizing Monoclonal Antibody Targeting the Acid-sensitive Region in Chikungunya Virus E2 Protects from Disease

Selvarajah S, et al., 7(9):e2423, PLoS Negl Trop Dis, 2013

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has produced up to 6.5 million cases of acute and chronic rheumatic disease. The authors describe the isolation and characterization of two human monoclonal antibodies, C9 and E8, from CHIKV infected and recovered individuals. C9 was determined to be a potent virus neutralizing antibody. The Octet RED system and AR2G biosensors were used to characterize binding of C9 to intact CHIKV VLPs.

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