A Neutralizing Anti-gH/gL Monoclonal Antibody is Protective in the Guinea Pig Model of Congenital CMV Infection

Auerbach MR, et al., 10(4):e1004060, PLoS Pathog, 2014

The authors performed structural and functional analysis on a neutralizing monoclonal antibody targeting an guinea pig envelope cytomegalovirus (CMV) glycoprotein H/glycoprotein L that can protect the fetus from infection. Binding of antibodies to guinea pig FcRn complexes was performed on the Octet QK system, using Amine-Reactive biosensors. The guinea pig is a model system for maternal-fetal transmission and the studies may provide insight into therapeutic intervention of neutralizing mAbs for CMV congenital infections in humans.

Read More