A Broadly Neutralizing Human Monoclonal Antibody Exhibits In Vivo Efficacy Against Both Human Metapneumovirus and Respiratory Syncytial Virus

Schuster J, et al., 211(2):216-25, J Infect Dis, 2015

The article describes neutralizing activity and affinity kinetics of a human mAb known as 54G10 against human metapneumovirus (HMPV). In vivo efficacy studies were carried out using a new mouse model called DBA/2. An Octet RED96 instrument equipped with Streptavidin biosensors was used to capture biotinylated B2F?TM. The titrations involve varying concentration of the mAb. The 54G10 showed subnanomolar affinity for the recombinant fusion protein HMPV B2F?TM.

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