Citations : Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells

Dated: Nov 27, 2020

Publication Name: Journal of Interferon & Cytokine Research

Multiple myeloma (MM) remains an intractable hematological malignancy, despite recent advances in anti-MM drugs. Here, we show that role of PDZ binding kinase (PBK) in MM tumor growth. We identified that interleukin-6 (IL-6) readily increases PBK expression. Kaplan–Meier analysis showed that the MM patients with higher expression of PBK have a significant shorter survival time compared with those with moderate/lower expression of PBK.

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Contributors: Akinobu Ota, Ichiro Hanamura, Sivasundaram Karnan, Shingo Inaguma, Norio Takei, Vu Quang Lam, Shohei Mizuno, Jo Kanasugi, Md Wahiduzzaman, Md Lutfur Rahman, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Hiroshi Ikeda, Akiyoshi Takami, and Yoshitaka Hosokawa