Citations : Measuring affinity constants of 1450 monoclonal antibodies to peptide targets with a microarray-based label-free assay platform

Dated: Jan 12, 2021

Publication Name: Journal of Immunological Methods

Monoclonal antibodies (mAbs) are major reagents for research and clinical diagnosis. For their inherently high specificities to intended antigen targets and thus low toxicity in general, they are pursued as one of the major classes of new drugs. Yet binding properties of most monoclonal antibodies are not well characterized in terms of affinity constants and how they vary with presentations and/or conformational isomers of antigens, buffer compositions, and temperature.

Read More

Contributors: J.P.Landry, Yaohuang Ke, Guo-Liang Yu, X.D.Zhu