Citations : Impaired antioxidant activity of high-density lipoprotein in chronic kidney disease

Dated: Feb 02, 2009

Publication Name: Translational Research

Chronic kidney disease (CKD) is associated with accelerated atherosclerosis and increased mortality from cardiovascular disease. CKD results in oxidative stress, inflammation, and high-density lipoprotein (HDL) deficiency, which work in concert to promote atherosclerosis. Normal HDL confers protection against atherosclerosis by inhibiting the oxidation of lipids and lipoproteins and by retrieving surplus cholesterol and phospholipids from lipid-laden cells in the artery wall for disposal in the liver (reverse cholesterol transport).

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Contributors: Hamid Moradi, Madeleine V.Pahl, Reza, Elahimehr, Nosratola D.Vaziri