Dated:
Oct 25, 2011
Publication Name:
Springer Nature
In adult human islets, insulin and glucagon production is largely restricted to individual cell populations. The production of these hormones is less segregated during development and during the differentiation of human pluripotent stem cells towards pancreatic lineages. We therefore sought to characterise the transcription factor profile of these cells that co-produce insulin and glucagon in the developing human pancreas, and thus to gain insight into their potential fate during normal pancreas development.
Read MoreContributors: M. J. Riedel, A. Asadi, R. Wang, Z. Ao, G. L. Warnock & T. J. Kieffer